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Peyronie's Disease Treatment
Non-surgical treatment options for penile curvature and plaque, phase-dependent and evidence-based. Not every patient needs surgery — and not every patient can avoid it.
Fibrous plaque, curvature, and often erectile dysfunction
Peyronie's disease is characterized by fibrous plaque formation within the tunica albuginea, producing penile curvature, deformity, pain, and — in many patients — erectile dysfunction. Surgical correction has historically been the definitive treatment, but the range of non-surgical options has expanded significantly in the past decade. For many patients they are the appropriate first line.
Treatment is phase-dependent
Oral, intralesional, traction, and regenerative — matched to phase
Oral therapy (pentoxifylline, L-carnitine, vitamin E, CoQ10) has modest evidence in the acute phase, best as adjunctive. Intralesional Xiaflex is the only FDA-approved therapy — indicated for stable curvature 30°–90°. Interferon alfa-2b and verapamil are off-label alternatives. Penile traction has evidence when used consistently over 3–6 months. Regenerative modalities (PRP, shockwave, stem cells) are adjunctive, not definitive.
Address curvature and erectile function together
A significant proportion of Peyronie's patients have concurrent erectile dysfunction. Treatment planning should address both simultaneously. PDE5 inhibitors, low-intensity shockwave therapy, and regenerative modalities are all part of the concurrent-ED toolkit alongside phase-appropriate curvature management.
Treated by the physicians who defined the field
Real patient experiences
I am extremely satisfied with the care I received here. The results are phenomenal and the value I receive at this location is very competitive. 10/10.
Manuel Martinez
Their experience is excellent, developed over a long time helping many. In the rare case of needing post-procedure guidance, they provided advice and counseling.
David Reynolds
LOREM IPSUM
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Nonsurgical Phalloplasty
Frequently Asked Questions
Do I need surgery for Peyronie's?
What is Xiaflex?
Does traction therapy actually work?
Can I be treated in the acute phase?
Get a phase-appropriate plan
Peyronie's treatment starts with an accurate assessment of your phase and severity. Book a consultation for a proper clinical evaluation before any treatment is recommended.